Device, programmed bioelectric signaling sequences and methods for the controlled expression up or down of the sonic hedgehog protein on demand
Leonhardt's Launchpads, a Los Angeles and Salt Lake City based innovation and startup accelerator focused on bioelectric and biologics based organ regeneration and recovery, today announced filing of patent application for bioelectrical stimulation signaling sequences able to control the release of the sonic hedgehog protein, a known powerful anti-aging and regeneration promoting protein.
The technology described in the patent involves precise bioelectric signaling sequences that communicate with the DNA and cell membranes within stimulated tissues to cause the cells to produce high volumes of the sonic hedgehog protein on demand.
“Our growing patent portfolio uniquely positions us at the forefront of bioelectric and stem cell biologics based organ regeneration and recovery,” said Howard J. Leonhardt, Executive Chairman and CEO, Leonhardt's Launchpads and inventor. "As leaders in this field, we continue to expand our intellectual property protections having filed over 180 new patent claims in 2018 alone and 2019 is on pace to exceed this level. We hope this soon translates to helping people to keep their own organs, regenerated back to full health, instead of getting artificial, animal or donor transplant implants."
By the terms of being part of the Leonhardt's Launchpads innovation and startup accelerator(s) all 30 startups in the accelerator have a no additional fee exclusive ownership license for their specific organ application. Leonhardt's Launchpads has 30 startups in these technology groups - Heart & Cardiovascular (9), Brain (1), Cosmetic & Personal Care (7), Major Organ Regeneration (12) and Cancer (1) - https://leonhardtventures.com/our-companies/ + https://leonhardtventures.com/development-pipeline/
"We hope to prove in well controlled studies the ability of this protein expression combined with others to regenerate full health to organs. The company is proceeding cautiously to move this technology into the clinic in careful steps." stated Dr. Leslie Miller Chief Medical Officer
The sonic hedgehog protein has been demonstrated or discovered to have a role in many organ regeneration applications which correspond with startups within our accelerator. A few examples are listed below.
- 2. EyeCell www.eye-cell.com > eye regeneration > https://iovs.arvojournals.org/article.aspx?articleid=2372930
- 3. LiverCell www.livercell.com > liver regeneration > https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920129/
- 4. PancreaCell https://leonhardtventures.com/pancreacell/> pancreas regeneration > https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666349/
- 5. CerebraCell www.cerebracell.com - brain regeneration > https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121355/
- 6. Vascustim www.vascustim.com - wound healing > https://www.ncbi.nlm.nih.gov/pubmed/26154888+ https://www.liebertpub.com/doi/abs/10.1089/9781934854280.171
- 7. HairCell www.haircellstim.com - hair regeneration > https://newatlas.com/sonic-hedgehog-gene-hair-regrowth/57435/
- 8. SkinSkim www.skin-stim.com - skin regeneration > https://yaledailynews.com/blog/2018/12/04/researchers-discover-new-skin-regeneration-mechanism/
- 9. MyoStim ED www.erectistim.com - erectile dysfunction > https://www.sciencedirect.com/science/article/pii/S1742706116300149
- 10. Regenalung https://leonhardtventures.com/regenalung/ lung regeneration > https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362576/
With this IP filing addition, Leonhardt's Launchpads intellectual property portfolio now includes over 300 patented or patent pending invention claims that have been issued, filed, optioned or licensed focused on organ regeneration or recovery.
"We are very proud of our R&D lab research staff members led by Sejal Chaudhari in our own Utah lab that worked long hours with many failed tries prior to discovering the right bioelectric signaling sequences to control the up regulation of the sonic hedgehog protein. We believe this is a landmark breakthrough in the field of bioelectric organ regeneration." stated Dr. Brett Burton, VP R&D & Startup Launches Leonhardt's Launchpads Utah, Inc.
Note - In some potential therapeutic uses different bioelectric signaling sequences, also being developed by the same team, may be used to down regulate sonic hedgehog protein expression.
About Leonhardt's Launchpads:
Leonhardt's Launchpads www.leonhardtventures.com is the innovation and startup accelerator arm of Leonhardt Ventures LLC focused on bioelectric and biologics based organ regeneration and recovery. The 2019 portfolio class has 30 startups - https://leonhardtventures.com/development-pipeline/. The accelerator business model is to advance each organ specific innovation through first-in-man studies and then seek a strategic partner for the balance of development.
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Howard J. Leonhardt
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See www.leonhardtventures.com for more information.
Leonhardt's Launchpads by Cal-X Stars Business Accelerator, Inc., 12655 W Jefferson Blvd, Los Angeles, CA 90066
Leonhardt Ventures LLC (Leonhardt Vineyards LLC DBA Leonhardt Ventures), 12760 Millennium Dr. Suite 213, Playa Vista, CA. 90094
Leonhardt's Launchpads Utah, Inc. 370 S, 300 E, Salt Lake City, UT 84111
Research Lab @ 2500 S State St. #224, Salt Lake City, UT 84115
Leonhardt’s Launchpads Pittsburgh, Inc.,2730 Sidney Street, Suite 300m Pittsburgh, PA 15203
Google Voicemail All Locations: (424) 291-2133
Warnings and Disclaimers: Patents pending may not be issued. Patents issued, licensed or optioned may not be maintained. Products are early stage in development and are not yet proven safe or effective. Company lacks sufficient resources to bring these products fully to commercialization. As an investment these early stage startups have to be regarded in the highest risk category for total loss. Forward looking statements are subject to change without notice. Any timelines, implied or quoted, are highly subject to change even by years.